Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics
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چکیده
منابع مشابه
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15 صفحه اولLC-MS multi-attribute method for characterization of biologics
(mAbs), are complex protein molecules produced from mammalian tissue culture cells through recombinant DNA technology. As a result of naturally-occurring molecular heterogeneity as well as chemical and enzymatic modifications during manufacture, process, and storage, there are many product quality attributes (PQAs) presenting in therapeutic proteins. These PQAs can potentially include: product-...
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ژورنال
عنوان ژورنال: mAbs
سال: 2015
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2015.1069454